Widespread effects were felt from Matthew across its destructive path, however, the most significant impacts were felt in Haiti, with US$2.8 billion in damage and 546 deaths, making Matthew the worst disaster to affect the nation since the 2010 earthquake. The remnants of Matthew continued to accelerate towards Canada where it was absorbed by a cold front. Matthew re-emerged into the Atlantic shortly afterward, eventually completing its transition into an extratropical cyclone as it turned away from Cape Hatteras, North Carolina on October 9. The storm then paralleled the coast of the southeastern United States over the next 36 hours, gradually weakening while remaining just offshore before making its fourth and final landfall over the Cape Romain National Wildlife Refuge near McClellanville, South Carolina as a Category 1 hurricane on the morning of October 8. Matthew weakened somewhat but re-intensified as it tracked northwest, making landfall in the northern Bahamas. Matthew weakened slightly and fluctuated in intensity while making a northward turn toward the Greater Antilles, remaining a strong Category 4 hurricane as it made its first landfall over Haiti's Tiburon Peninsula early on October 4, and then a second one in Cuba later that day. This strength was attained at just 13.4°N latitude – the lowest latitude ever recorded for a storm of this intensity in the Atlantic basin, breaking the record set by Hurricane Ivan in 2004.
It became a hurricane north of Venezuela and Colombia on September 29, before undergoing explosive intensification, ultimately reaching Category 5 intensity on October 1 with peak 1-minute sustained winds of 165 mph.
Originating from a tropical wave that emerged off Africa on September 22, Matthew developed into a tropical storm just east of the Lesser Antilles on September 28. Matthew also approached the southeastern United States, but stayed just offshore, paralleling the Florida coastline. It caused extensive damage to landmasses in the Greater Antilles, and severe damage in several islands of the Bahamas which were still recovering from Joaquin, which had pounded the archipelago nearly a year earlier. The deadliest Atlantic hurricane since Hurricane Stan in 2005, Matthew was the thirteenth named storm, fifth hurricane and second major hurricane of the 2016 Atlantic hurricane season. Matthew caused catastrophic damage and a humanitarian crisis in Haiti, as well as widespread devastation in the southeastern United States. Hurricane Matthew was the first Category 5 Atlantic hurricane since Felix in 2007.